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SS-31 (50mg)

Table of Contents

  • Quickstart Highlights

SS-31 (50mg), also known as elamipretide, is a mitochondria-targeting tetrapeptide studied for its potential role in improving cellular energy production and reducing oxidative stress. It selectively interacts with cardiolipin in the inner mitochondrial membrane, supporting mitochondrial structure and efficiency. This guide outlines a subcutaneous administration approach optimized for the 50 mg vial format.

  • Reconstitute: Add 2.0 mL bacteriostatic water → 25 mg/mL concentration
  • Typical daily range: 250–1000 mcg per day (subcutaneous, research-based range)
  • Easy measuring: At 25 mg/mL, 1 unit = 0.01 mL = 250 mcg on a U-100 insulin syringe
  • Storage: Lyophilized: store at −20 °C; after reconstitution, refrigerate at 2–8 °C and use within 2–4 weeks
  • Protocol Overview

Concise summary of the subcutaneous regimen.

  • Goal: Support mitochondrial function, cellular energy, and oxidative stress reduction
  • Schedule: Daily subcutaneous injections; consistent timing preferred
  • Dose Range: 250–1000 mcg per day (research-based range)
  • Dosing Protocol

Suggested approach for the 50 mg vial format.

  • Start: 250 mcg once daily to assess tolerance
  • Target: 500–1000 mcg per day, depending on response and protocol
  • Frequency: Once daily (subcutaneous)
  • Vial Duration: One 50 mg vial can last multiple weeks, depending on dosing
  • Timing: Morning or consistent daily timing preferred for steady mitochondrial support
  • Mechanism of Action

SS-31 (elamipretide) is a synthetic tetrapeptide that selectively targets mitochondria, where it binds to cardiolipin—a key phospholipid in the inner mitochondrial membrane. This interaction helps stabilize mitochondrial structure and improve electron transport chain efficiency.

By supporting mitochondrial integrity, SS-31 may reduce excessive reactive oxygen species (ROS) production and improve ATP (cellular energy) output. This makes it of interest in research involving age-related decline, metabolic dysfunction, and conditions associated with mitochondrial stress.

  • Potential Benefits & Side Effects

Observations based on preclinical and clinical research literature.

Potential Benefits:

  • May support improved mitochondrial energy production
  • May reduce oxidative stress at the cellular level
  • May enhance endurance and cellular recovery
  • Investigated for potential benefits in age-related and metabolic conditions

Possible Side Effects:

  • Mild injection-site irritation
  • Occasional headache or fatigue during adaptation
  • Limited long-term safety data in healthy populations
  • Remains investigational in many use contexts