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SS-31 (10mg)

Table of Contents

  • Quickstart Highlights

SS-31 (10mg), also known as elamipretide in research contexts, is a mitochondria-targeting peptide studied for its potential role in supporting cellular energy production, reducing oxidative stress, and improving mitochondrial efficiency. It is primarily investigated for its effects on cellular aging, metabolic function, and tissue protection. This guide outlines a subcutaneous research-use protocol format for the 10 mg vial.

  • Reconstitute: Add 2.0 mL bacteriostatic water → 5 mg/mL concentration
  • Typical research range: 2–10 mg per day (subcutaneous, study-dependent)
  • Easy measuring: At 5 mg/mL, 1 unit = 0.01 mL = 50 mcg (0.05 mg) on a U-100 insulin syringe
  • Storage: Lyophilized: store at −20 °C; after reconstitution, refrigerate at 2–8 °C and use within 2–4 weeks
  • Protocol Overview

Concise summary of the research-use regimen.

  • Goal: Support mitochondrial function and reduce oxidative stress at the cellular level
  • Schedule: Typically administered daily in research settings
  • Dose Range: 2–10 mg per day, depending on study design
  • Dosing Protocol

Suggested research-use approach for the 10 mg vial format.

  • Start: 2 mg per day to observe response in research models
  • Target: 5–10 mg per day, depending on protocol design
  • Frequency: Once daily (subcutaneous in most research applications)
  • Vial Duration: One 10 mg vial lasts approximately 1–5 days, depending on dosing
  • Timing: Flexible; often administered at a consistent daily time in studies
  • Mechanism of Action

SS-31 (elamipretide) is a synthetic tetrapeptide designed to selectively target and accumulate in the inner mitochondrial membrane. It interacts with cardiolipin, a key phospholipid that supports mitochondrial structure and function.

By stabilizing cardiolipin, SS-31 may help improve electron transport chain efficiency, reduce the production of reactive oxygen species (ROS), and support ATP (energy) production. These effects make it a focus of research in conditions involving mitochondrial dysfunction, oxidative stress, and age-related cellular decline.

  • Potential Benefits & Side Effects

Observations based on preclinical and clinical research literature.

Potential Benefits:

  • May support mitochondrial energy production (ATP efficiency)
  • May reduce oxidative stress at the cellular level
  • May improve cellular resilience and recovery
  • Investigated for potential benefits in age-related and metabolic conditions

Possible Side Effects:

  • Mild injection-site reactions
  • Temporary fatigue or headache in some research reports
  • Generally well tolerated in clinical studies
  • Long-term effects are still under investigation; research is used only in many regions